http://www.scdmvonline.com/DMVNew/forms/400.pdf
Obtaining a Duplicate Title
If you have lost your title, you may obtain a duplicate title from the Department of Motor Vehicles. You may apply for the duplicate title by mail or by visiting your local SCDMV field office. The Form 400, Application for Certificate of Title/Registration, which must be completed, contains the proper mailing address for the department.
To obtain a duplicate title, you must have the following:
Completed Form 400, Application for Certificate of Title/Registration.
To complete the form, you must have your vehicle odometer mileage reading and any current lien information.
Acceptable Identification
Title Fee.
The title fee is $15.00.
Important note: If there is a lien on your vehicle, the duplicate title will be sent to the lien holder.